Engrail Therapeutics

Engrail Therapeutics

Private
San Diego, CaliforniaHealthcare & Life Scienceshttps://engrail.com/

Last Round

Series B

Extension

Aug 8, 2024

Total Funding Raised

$241M

Momentum Score

25 /100

Company Overview

Engrail Therapeutics is a clinical-stage pharmaceutical company focused on developing and delivering transformational therapies for patients with neuropsychiatric and neurodevelopmental disorders. Founded in 2019, the company aims to become a leader in neuroscience by uniting biological insights with clinically meaningful solutions. Engrail's pipeline includes treatments for diseases with significant unmet medical needs, such as anxiety disorders, depression, post-traumatic stress disorder (PTSD), and rare neurodegenerative diseases. The company is advancing multiple programs, including its lead asset ENX-102, which is in a Phase 2 study for generalized anxiety disorder. Engrail has raised over $220 million since its inception, including a $157 million Series B round in March 2024, to propel its pipeline through various stages of clinical development.

Sector

Healthcare & Life Sciences

Verticals

Biotechnology, Clinical Trials, Drug Discovery, Mental Health, Precision Medicine

Business Model

B2B2C

Customer Profile

Revenue Share

AI Layer

Non-AI

Keywords

GABA-A PAMprecision neuroscienceCNS drugsanxiety disorder treatmentclinical-stage biotechbenzodiazepine alternativesubtype-selective modulatornon-sedating anxiolyticgeneralized anxiety disorderGADneuropsychiatric disorderssmall-molecule drugsdepression treatmentPTSD treatmentdrug pipelineMenkes disease

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Caplight Momentum Score

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Engrail Therapeutics Comps

Public and private peers based on sector, stage, and business model.

CompanyStatusEst. ValuationRev Multiple
OpenAIPrivate$86.0B~40x
CoherePrivate$5.0B--
Competitor 1Public$XX.XBXXx
Competitor 2Public$XX.XBXXx

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Engrail Therapeutics Funding Rounds

Historical fundraising activity

RoundDateAmount RaisedValuationInvestorsSources
Series B ExtensionAug 8, 2024
Series BMar 19, 2024
Series A ExtensionAug 3, 2021
Series AJun 18, 2020

Key People

Founding team and executive leadership

Stephen Cunningham

Co-Founder And Chief Development Officer

Founding Team

Vikram Sudarsan

President And CEO, Co-founder

Founding Team

Paul Cayer

Chief Financial Officer

Executive Team

Engrail Therapeutics Investors

Notable investors and investment history

InvestorRounds
F-Prime CapitalSeries B
Eight Roads VenturesSeries B
Ysios CapitalSeries B
Nan Fung Life SciencesSeries A Extension, Series A
Norwest Venture PartnersSeries B
RiverVest Venture PartnersSeries B
Foresite CapitalSeries B, Series B Extension

Market signals

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  • Jul 16, 2025

    ENX-101 evaluated for antiseizure effects in GAERS model.

Engrail Therapeutics Filings

SEC and related filings with document metadata.

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Engrail Therapeutics Filings

SEC and related filings with document metadata.

Frequently Asked Questions

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Firmographic Details

HeadquartersSan Diego, California
Employee Range35
Year Founded2019
Last FundingAug 8, 2024

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