Siren Biotechnology

Private

San Francisco, CaliforniaHealthcare & Life Scienceshttps://sirenbiotechnology.com/

Last Round

Grant

Jun 26, 2026

Est. Valuation

$64.2M

Total Funding Raised

$48.43M

Company Overview

Siren Biotechnology is a biotechnology company developing Universal AAV Immuno-Gene Therapy, which combines AAV gene therapy and cytokine immunotherapy, to treat solid tumors.

Sector

Healthcare & Life Sciences

Verticals

Biotechnology, Drug Discovery, Precision Medicine, Clinical Trials

Business Model

B2B

Customer Profile

Services & Consulting

AI Layer

Non-AI

Keywords

gene therapyadeno-associated virusAAVimmuno-gene therapysolid tumor treatmentcytokine immunotherapyglioma treatmentbiotechcancer immunotherapyprecision medicinenext-gen biologicsdrug discoveryclinical-stage biotechtumor microenvironmentbiopharma

Historical Pricing

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Siren Biotechnology Comps

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Siren Biotechnology comps — public and private peers by sector, stage, and business model
Company	Status	Est. Valuation	Rev Multiple
OpenAI	Private	$86.0B	~40x
Cohere	Private	$5.0B	--
Competitor 1	Public	$XX.XB	XXx
Competitor 2	Public	$XX.XB	XXx

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Siren Biotechnology Funding Rounds

Historical fundraising activity

Data table
Round	Date	Amount Raised	Valuation	Investors	Sources
Grant	Jun 26, 2026
Crowdfunding	Mar 15, 2026
Crowdfunding	Nov 3, 2025
Series A	Apr 22, 2024
Grant	Nov 1, 2023
Seed	Sep 1, 2021

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Key People

Founding team and executive leadership

Nicole K. Paulk

CEO, Founder, President

Founding Team

Siren Biotechnology Investors

Notable investors and investment history

Siren Biotechnology investors
Investor	Rounds
NZVC	Series A
Carnrite Ventures	Series A
Innovation Endeavors	Seed, Series A
Pathfinder Venture Capital	Crowdfunding, Series A, Seed
ARTIS Ventures	Series A, Seed
Lux Capital	Crowdfunding, Series A, Seed
California Institute for Regenerative Medicine	Grant

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Siren Biotechnology Filings

SEC and related filings with document metadata.

Data table
Typed	Date	Amount Offered	Amount Sold	Filling	Pages	Download
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Siren Biotechnology Filings

SEC and related filings with document metadata.

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Firmographic Details

HeadquartersSan Francisco, California

Employee Range9

Year Founded2020

Last FundingJun 26, 2026

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